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TLDR
Most of us don't have time to read the research. We take what the algorithm feeds us, or whatever a search happens to turn up. To improve that, I took inventory: the highest-traffic health websites and the most-followed YouTube channels, their brain-supplement advice gathered up to show where they agree and where they don't. The consensus is here so your brain doesn't have to hurt hunting for it.
Next week we narrow it down, weighing the research against what I've tested myself.

Hello self-aware brain,

If you subscribed this week (about half of you have, thank you) I suggest going back to review the foundation → a set of self-care habits that research shows will help us improve our neurocognitive performance (if we adhere to them).

Brain health foundations recap

  • Consistent sleep quality

  • Aerobic physical training

  • Resistance training (any type)

  • Mediterranean/MIND-style dietary

  • Heart health and disease prevention

  • Desirable cognitive difficulty (neurotransmitter exercise)

  • Stress (cortisol) management

  • Positive social connection

  • Frequent movement

  • Sensory (eye, ear) and neurotoxin (alcohol) protection

In the second entry, the first floor on that foundation, we opened brain health nutrition. Because, by both evidence and definition, supplements should supplement whole foods.

Brain health nutrition recap

  • Omega-3 Fatty Acids (EPA, DHA, and ALA)

  • Choline

  • B9 (Folate)

  • B12

  • Polyphenols

  • Flavonoids

  • Creatine, Carnitine, Carnosine (Zoonutrients)

  • Iron

  • Boron

  • Iodine

  • L-Tyrosine

Caffeine, not a nutrient, is removed from this list. But it is part of the MIND diet, and it keeps coming up across top supplement recommendations. We'll dive into the deep end of reasons for that in a future BrainHealth.news letter. Stay tuned!

Last week we established which of these nutrients to consume via whole foods, which as supplements, and why. Our third floor.

Now for the fourth edition (or floor) on Structural Brain Health: Expanding the cognitive enhancement supplements list.

So far, our house of brain health is based on research by Dr. Morris, supporting the MIND diet’s peer-reviewed, time-tested advantages.1 But here’s the disadvantage. Her research points primarily toward mitigating cognitive decline, long term. Healthspan is important too, of course. But my readers and I want quick cognitive performance gains too. Those measurable in hours, not only years. That’s our focus today.

I’m not abandoning an expanded list of nutrients/supplements that provide durable long-term neuroprotection. On the contrary, I plan to expand on it as well. Coming soon to an inbox near you.

Only three of the neurocognitive/brain health nutrients identified so far in this series, for building Structural Brain Health, provide same-day cognitive enhancement benefits:

  • Choline (Alpha-GPC specifically)

  • Creatine

  • L-Tyrosine

Diverge To Converge

To expand on this, I believe my educated, highly intelligent, well informed reader might have the same epistemological question I do: How do we know what supplements to take?

The short answer is evidence. So where do we get it? For most of us, the interwebs.

Most of us aren’t doing biochemical research. So we listen to those who are. But here’s the thing, few publishing scientists are active on web/social channels, except where their research is published. The next best thing for us is what’s most available - high profile practitioners and journalists the web and social algorithms serve up. Altogether, a very mixed bag indeed. A whole lotta hype’n happen’n.

So let’s turn up the signal, and reduce the noise.

I’ve taken the following inventory of supplement recommendation sources with the intent to help my beloved reader contextualize and evaluate recommendations through a lens of high-level media consensus. Then summarize those most relevant today.

It isn’t perfect. My intent is to improve our predicament in an age of hyper-intensive marketing and overwhelming content volumes, from a new or improved sense of the consensus among the top web/social channels we’re regularly exposed to.

Discovery has a push and a pull side. Push is social media algo’s feeding us more of anything we signal interest in behaviorally. Pull is opening a web browser and typing terms we think should show us what we’re interested in. Unsurprisingly, these two discovery modes have demographic differences. Mainly, by age group.

Generation cohort

Health/wellness sources by platform

Gen Z (≈18–27)

1. Instagram 30.4%
2. TikTok 23.2%
3. http web/search 18.8%
4. YouTube 14.5%

Millennials (≈28–44)

1. http web/search 42.4%
2. YouTube 21.2%
3. Instagram 17.2%
4. TikTok 11.1%

Gen X (≈45–60)

1. http web/search 41.1%
2. YouTube 29.5%
(Instagram/TikTok %’s not readily available)

Boomers (≈61–79)

1. http web/search 55.9%
2. YouTube 25.2%
(Instagram/TikTok %’s not readily available)

Bars scaled to a 56% max. for closer comparison. Figures: Grin 2025

Web vs socials are not equally trusted, however. While social wins reach, web generally wins on trust, primarily from more institutional sources i.e. hospitals and universities.

Top Brain Health Supplement Recommendations Online

Initially, I’d planned to provide you the top five channels who recommend brain health and cognitive performance supplements per platform. But IG and TikTok data are not entirely or readily available for today’s email/post. Apologies. However, I plan to spin up the APIs and services/python to gather them for future emails/posts. Stay tuned.

Meanwhile I’ll provide you the data available for the top two supplement recommendation channels we use: Web still beats YouTube search by volume across the 18-79 age range as a whole. So web first.

Top Seven Websites Recommending Brain Health Supplements

Because of the number of variables, like potentially relevant search keyword or key phrase combinations, I’ve first ranked web sources by total traffic volume (source: Similarweb.com). Secondly, only those with “brain health supplement” recommendations in SERPS (excluding ecom and sponsored results). Lastly, I include one site editorially for highly relevant science data and recommendation quality, instead of search volume.

Health-category websites where U.S. consumers discover supplement recommendations. Ranked by Similarweb estimated monthly visits. Positive supplement endorsements.

Source

Visits/mo.

Posts indexed

Supplements recommended
(source’s order)

Healthline
healthline.com

50.6M

Top 5

Omega-3
Resveratrol
Caffeine (Recurring non-nutrient)
Phosphatidylserine
Acetyl-L-Carnitine
Ginkgo biloba
Creatine
Bacopa monnieri
Rhodiola rosea
SAMe (S-adenosyl-L-methionine)

31.4M

Top 5

B vitamins (B6 B12 B9)
Caffeine (again, non-nutrient)
L-Theanine
Omega-3
E (Vitamin)
Ginkgo biloba
Ginseng
Curcumin (polyphenol)
CDP-choline

GoodRx
goodrx.com

21.6M

Top 5

Omega-3
D3
B12
Zinc
L-Theanine
Choline
CoQ10
Resveratrol
Curcumin (polyphenol)
Ashwagandha
Lion's mane
Phosphatidylserine

Medical News Today medicalnewstoday.com

17.9M

Top 5

Omega-3
B vitamins (B6 B12 B9)
E (Vitamin)
Caffeine (again)
L-Theanine
Creatine
Resveratrol
Acetyl-L-carnitine (underrated IMHO)
Ginkgo biloba
Bacopa monnieri
Rhodiola rosea
Panax ginseng

Verywell Health verywellhealth.com

15.6M

Top 5

B vitamins (B6 B12 B9)
D3
Iron
Omega-3
Phosphatidylserine
Ashwagandha
Panax ginseng
Huperzine A
Magnesium L-threonate

University Hospitals uhhospitals.org

2M (est.)

1

B vitamins (B6 B12 B9)
Omega-3
Ginkgo biloba
Phosphatidylserine
Curcumin (polyphenol)

Examine
examine.com

Editorially compelled to include it based on qualitatively higher ranking as a practictioner’s science research platform. A top source used by other sources.

n/a

n/a

Acetyl-L-Carnitine
Alpha-GPC
Bacopa monnieri
Caffeine
Citicoline (CDP-Choline)
Creatine monohydrate
Ginkgo biloba
Huperzine A
L-Theanine
Panax ginseng
Phosphatidylserine
Rhodiola rosea
Uridine monophosphate (UMP)

Top Seven YouTube Channels Recommending Brain Health Supplements

Health category channels that post long-form brain-supplement content. Ranked by subscribers. Videos recommending specific supplement compounds only are included.

Channel

Sub’s

# Videos indexed

Supplements recommended
(source’s order)

Dr. Eric Berg DC
@drericberg

14.7M

Top 5

Omega-3
D3
B vitamins (B6 B12 B9)
Magnesium
Zinc
K2
TMG / betaine (unique!)
Lion's mane

Andrew Huberman
@hubermanlab

7.53M

3

Omega-3s
Creatine
Alpha-GPC
L-Tyrosine
Phosphatidylserine

Dr. Tracey Marks
@DrTraceyMarks

2.38M

Top 5

Omega-3
B vitamins (B6 B12 B9)
Magnesium
CoQ10

Dr. Boz
@DoctorBoz

1.24M

1

Omega-3

D3

K2

Rhonda Patrick
@FoundMyFitness

683K

4

Sulforaphane
Creatine
Omega-3/DHA
Choline
D3

Dr Brad Stanfield
@DrBradStanfield

331K

4

Omega-3
Creatine
Multivitamin

Dr. LeGrand
@doctorlegrand

166K

Top 5

Ginkgo biloba
Bacopa monnieri
D3
K2
Omega-3
Iron
B vitamins (B6 B12 B9)
L-Theanine

For both the top web and youtube channel supplement recommendations above, I’ve shown all compounds for you. Yet our main focus today is same-day cognitive enhancers, aka nootropics.

Convergence at Last

Here’s the list without vitamins, minerals, long-term neuroprotections, and those already covered in Structural Brain Health series recaps above, with a count of occurrences.

Direct Cognitive Enhancers

  • Phosphatidylserine (6)

  • Ginkgo biloba (6)

  • Caffeine (5 - again, a stimulant, not a nutrient, but it keeps showing up!)

  • L-Theanine (5)

  • Bacopa monnieri (4)

  • Huperzine A (2)

Indirect Cognitive Enhancers

  • Ginseng (4 - web only)

  • Ashwagandha (3)

  • Acetyl-L-carnitine (3)

  • Rhodiola rosea (3)

Note: I’m not recommending any or all of these nutrient isolates to anyone, yet.

Next week we’ll winnow down and weed-out this list, based on both sturdy science and my personal experience. Yours too is requested. 🤓

Soon we’ll also continue our discovery journey by considering more bioavailability and bioaccessibility factors, such as time of day and combined consumption synergies? Please let me know in web comments.

Stay active, self-aware brains!

🫶🏽

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